Related Experiment Video
Updated: Jul 18, 2026
10:10
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
[Ganglionopathies: evolving concept and ideas on management]
1Unité Nerf-Muscle, Service de Neurologie, CHU Vaudois, Lausanne, Suisse. thierry.kuntzer@chuv.ch
Revue Neurologique
|December 8, 2006
Summary
Sensory ganglionopathies, affecting dorsal root ganglion cells, often link to cancer or autoimmune issues. Distinctive signs include unsteady gait and hand movements, with global sensory nerve signal loss.
Area of Science:
- Neurology
- Neuroscience
- Pathology
Context:
- Sensory ganglionopathies are neurological disorders impacting dorsal root ganglion cells.
- They are frequently associated with neoplastic (cancer-related) or dysimmune (autoimmune) disorders.
- Common triggers include chemotherapy drugs like cisplatin, vitamin B6 (pyridoxine) toxicity, and inherited conditions.
Purpose:
- To review recent advancements in understanding the mechanisms of sensory ganglionopathies.
- To outline the differential diagnosis of these conditions.
- To highlight the distinct characteristics of sensory nerve action potentials in chronic sensory ganglionopathies.
Summary:
- Sensory ganglionopathies present with unsteady gait and pseudoathetoid hand movements.
- Unlike other sensory neuropathies, they show a global reduction in sensory nerve action potential (SNAP) amplitudes, not just distal.
- This review covers mechanisms, differential diagnosis, hereditary neuronopathies, and infectious causes.
Impact:
- Enhances understanding of the underlying mechanisms of sensory ganglionopathies.
- Provides a framework for accurate differential diagnosis, distinguishing from other sensory neuropathies.
- Improves clinical recognition and management of patients with these complex neurological conditions.
Related Concept Videos
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:24Nephrotic Syndrome III : Nursing Management
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
01:30Acute Pancreatitis II: Clinical Manifestations and Management
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
01:23Atherosclerosis IV: Nursing Management
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...