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How repeatable is a faecal egg count reduction test?

C M Miller¹, T S Waghorn, D M Leathwick

¹AgResearch, Grasslands, Private Bag 11008, Palmerston North, New Zealand.

New Zealand Veterinary Journal

|December 8, 2006

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Faecal egg count reduction tests (FECRT) show considerable variability in results. Caution is advised when interpreting FECRT efficacy between 90-95%, as a high result may still indicate resistant parasites.

Area of Science:

Veterinary Parasitology
Anthelmintic Resistance
Sheep Health

Background:

Faecal egg count reduction tests (FECRT) are crucial for diagnosing anthelmintic resistance in livestock.
Variability in FECRT methodologies can impact the reliability of resistance diagnosis.
Accurate FECRT interpretation is vital for effective parasite control strategies in sheep.

Purpose of the Study:

To assess the repeatability of FECRT by evaluating different calculation methods and intra-method variations.
To provide veterinarians with data to confidently diagnose anthelmintic resistance using FECRT.
To understand the impact of calculation methods on FECRT efficacy estimates.

Main Methods:

Two commercial sheep farms with known reduced efficacy to ivermectin or albendazole were selected.

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Over 250 lambs per farm were sampled for faecal nematode egg counts (FEC) and sorted into treatment and control groups.

FECRT efficacy was calculated using three different equations, and efficacy against specific parasite genera was determined via larval cultures.

Main Results:

Different FECRT calculation equations yielded varying efficacy estimates, with methods excluding untreated controls showing lower efficacy.
Larval cultures revealed considerable variation in parasite genera proportions, with some genera showing differential distribution based on FEC levels.
Estimated efficacy against individual parasite genera varied, and a significant proportion of tests failed to meet the > or =95% FECR threshold.

Conclusions:

FECRT outcomes and larval culture results demonstrated significant variability.
Interpreting FECRT results within the 90-95% efficacy range requires caution due to potential variability.
Even FECRTs estimating > or =95% efficacy may not rule out the presence of resistant parasites, suggesting a risk of false-negative results.