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Related Experiment Videos

ATP-activated channels in excitable cells.

B P Bean1, D D Friel

  • 1Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115.

Ion Channels
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Extracellular ATP activates cation channels in excitable cells like muscle and neurons. Further research is needed to understand these ATP-activated channels and their physiological roles.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Physiology

Background:

  • Extracellular adenosine triphosphate (ATP) is recognized as a key signaling molecule.
  • ATP modulates various ionic channels in excitable cells, including muscle and neurons.
  • These channels are crucial for cellular excitability and signaling.

Purpose of the Study:

  • To review the current understanding of ATP-activated and ATP-modulated ionic channels.
  • To highlight similarities and differences in these channels across various cell types.
  • To identify knowledge gaps and future research directions, particularly regarding pharmacological tools.

Main Methods:

  • Literature review of studies on ATP-activated and modulated ion channels.
  • Comparative analysis of channel properties (ionic selectivity, pharmacology) in different cell types.

Related Experiment Videos

  • Discussion of potential roles and mechanisms of ATP signaling.

    • Main Results:

    • A class of cation-permeable ATP-activated channels exists in skeletal muscle, cardiac muscle, smooth muscle, and neurons, showing similar but not identical properties.
    • These channels typically reverse near 0 mV and mediate excitatory effects upon ATP activation.
    • ATP also modulates voltage-dependent channels and channels activated by other transmitters, with potential second-messenger pathways yet to be fully elucidated.

    Conclusions:

    • ATP-activated channels represent a significant class of ion channels with diverse roles in excitable cells.
    • Further investigation is required to fully characterize these channels, their subtypes, and their physiological significance.
    • Development of specific pharmacological agents is essential for distinguishing channel subtypes and assessing their roles.