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Working with Human Tissues for Translational Cancer Research

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Clinical research at a crossroads: the NIH roadmap.

Elias A Zerhouni¹

¹National Institutes of Health, Office of Communication and Public Liaison, 9000 Rockville Pike, Room 344, Bethesda, MD 20892-0188, USA. burklowj@od.nih.gov

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research

|December 13, 2006

Summary

The National Institutes of Health (NIH) invests in biomedical research to improve national health through scientific translation. Strategic decisions and programs like the Clinical and Translational Science Awards (CTSA) aim to accelerate discovery and pre-empt illness.

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Area of Science:

Biomedical Research
Translational Science
Public Health

Background:

NIH investment has driven significant health advances over 30 years through scientific translation.
Rising research and healthcare costs necessitate strategic decision-making for maximizing NIH investment returns.
Preventing end-stage disease via molecular knowledge and behavioral interventions is crucial for national health maintenance.

Purpose of the Study:

To accelerate scientific discovery and its translation into patient care.
To foster a collaborative research environment and address scientific challenges.
To establish an academic home for clinical and translational science.

Main Methods:

Development of the NIH Roadmap for Biomedical Research.
Funding innovative programs to tackle scientific challenges.
Implementation of the Clinical and Translational Science Awards (CTSA) program.

Main Results:

Creation of an incubator for innovative research programs.
Fostering a new culture of inter-researcher cooperation and collaboration.
Addressing barriers between basic and clinical research and complexities in clinical research.

Conclusions:

The NIH Roadmap and CTSA program are vital for speeding scientific translation and improving public health.
Strategic vision and adaptation are essential for the NIH to meet future scientific and public health needs.
NIH's future actions will be guided by scientific community requirements and national public health demands.