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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[High grade transitional cell carcinoma with signet ring cell pattern. Case report]
F J Torres Gómez1, A García Escudero, F J Torres Olivera
1Servicio de Anatomía Patològica, Hospital de Jerez de la Frontera, Cádiz, España. javiertorresgomez@yahoo.es
Objective:
The presence of signet ring cells within a transitional cell carcinoma is a factor of poor prognosis.
Methods:
We report the case of a 69-year-old male patient with the diagnosis of high grade transitional cell carcinoma with signet ring cell pattern, the presence of which could have been foreseen in serial cytological tests performed after the clinical debut.
Results:
To achieve such a diagnosis, it is necessary to rule out the possibility of metastasis or infiltration of a neoplasia from other organ.
Conclusion:
Both the presence of an in situ neoplasia or the coexistence of infiltrative transitional cell tumor can help to determine primary origin of these neoplasias.
