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Effect of insect growth regulators on protein pattern of dermatophagoides farinae and its validity on inducing human
Said A M Mazyad1, Khairy A Mohammad
1Research and Training Center on Vectors of Diseases, Ain Shams University, Cairo, Egypt.
Abstract:
Two insect growth regulators, Methorprene and Hydroprene were evaluated as growth hormones on the common house dust mite; Dermatophagoides farinae. The adults and immature stages were treated with 4 concentrations of each regulator as contact and as diet. The data were recorded 30 & 90 days post-exposure. Both compounds significantly suppressed population growth, as compared to > or = 5% acetone controls. Methoprene was more effective than Hydroprene when given in diet by corporation bioassays but, slightly more effective for the 1st 30 days of the contact assays. A second set of contact and diet-incorporation assays was done using a 75% of Methoprene and Hydroprene to determine efficacy on D. farinae population dynamics, at weekly intervals for 13 weeks. The average number of the mites in the untreated control population was increased by more than 10 times than the original ones. On the other hand, the number of treated mites was not significantly increased. This was similar for both the contact and the diet-incorporation bioassays, although the average number of mites/container was significantly higher when the treatment was incorporated in the house dust mite diet than when applied directly as contact. Consequently, the insect growth regulators minimized the allergic efficacy of D. farinae in experimental exposed mice.
Insights
Insect growth regulators Methoprene and Hydroprene effectively suppressed populations of the common house dust mite (Dermatophagoides farinae). These compounds reduced mite numbers in both contact and diet-based treatments, minimizing allergic potential.
Area of Science:
- Entomology
- Allergology
- Pest Management
Background:
- The common house dust mite, Dermatophagoides farinae, is a significant allergen.
- Insect growth regulators (IGRs) offer potential for pest control by disrupting development.
Purpose of the Study:
- To evaluate the efficacy of two IGRs, Methoprene and Hydroprene, against Dermatophagoides farinae.
- To assess the impact of IGRs on mite population dynamics and allergic potential.
Main Methods:
- Adult and immature D. farinae were treated with varying concentrations of Methoprene and Hydroprene via contact and diet.
- Mite populations were monitored at 30 and 90 days post-exposure, with a longer-term study over 13 weeks.
- Experimental mice exposed to treated mites showed minimized allergic responses.
Main Results:
- Both Methoprene and Hydroprene significantly suppressed D. farinae population growth compared to controls.
- Methoprene demonstrated higher efficacy in diet-based assays, while Hydroprene showed slightly better initial contact efficacy.
- Diet incorporation of IGRs resulted in higher mite reduction than direct contact application.
Conclusions:
- Insect growth regulators Methoprene and Hydroprene are effective tools for controlling Dermatophagoides farinae populations.
- IGR treatment can mitigate the allergic impact of house dust mites.
- Diet incorporation may be a more effective delivery method for IGRs against D. farinae.
