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Updated: Jul 18, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
Ultraviolet light and cutaneous lupus
Marc Bijl1, Cees G M Kallenberg
1Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.bijl@int.umcg.nl
Abstract:
Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining the development of inflammation in lupus patients. We review the role of apoptotic cells and autoantibodies in the pathogenesis of UVB induced skin lesions.
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