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Related Concept Videos

Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Ultraviolet–visible (UV–visible or UV–Vis) spectroscopy is an analytical technique that investigates the interaction between matter and UV–Vis light within the electromagnetic spectrum. This method is widely used for its versatility, simplicity, and relatively quick data acquisition, making it valuable for both qualitative and quantitative analysis. When UV–Vis radiation passes through a material,  molecules absorb light depending on the energy required for electronic transitions. As a result...
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Studying Chronic Exposure of Mice to Ultraviolet B Radiation
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Published on: August 19, 2025

Ultraviolet light and cutaneous lupus.

Marc Bijl1, Cees G M Kallenberg

  • 1Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.bijl@int.umcg.nl

Lupus
|December 13, 2006
PubMed
Summary

Ultraviolet (UV) light, especially UVB, triggers skin disease in lupus patients by inducing cell death (apoptosis). Impaired removal of these apoptotic cells contributes to inflammation in UVB-induced lupus skin lesions.

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Area of Science:

  • Dermatology
  • Immunology
  • Photobiology

Background:

  • Ultraviolet (UV) radiation is a known trigger for cutaneous lupus erythematosus (CLE) flares.
  • UVB exposure induces apoptosis (programmed cell death) in skin cells.
  • Dysfunctional clearance of apoptotic cells is implicated in the pathogenesis of autoimmune diseases like lupus.

Purpose of the Study:

  • To review the role of apoptotic cells in the development of skin lesions in systemic lupus erythematosus (SLE) patients following UVB exposure.
  • To examine the contribution of autoantibodies to the pathogenesis of UVB-induced lupus skin lesions.

Main Methods:

  • Literature review focusing on UV radiation, apoptosis, and lupus pathogenesis.
  • Analysis of existing research on the mechanisms linking UVB exposure to skin inflammation in SLE.
  • Synthesis of data regarding the role of apoptotic cells and autoantibodies.

Main Results:

  • UVB is a potent inducer of apoptosis in keratinocytes and other skin cells.
  • Impaired clearance of apoptotic cells leads to the accumulation of cellular debris and autoantigens.
  • Autoantibodies targeting apoptotic cells and their components contribute to sustained inflammation and tissue damage.

Conclusions:

  • UVB-induced apoptosis and subsequent impaired clearance of apoptotic cells are critical events in the pathogenesis of lupus skin lesions.
  • Autoantibodies play a significant role in amplifying the inflammatory response to UVB-induced cellular damage in lupus patients.
  • Understanding these mechanisms may lead to targeted therapies for preventing or treating UVB-induced cutaneous lupus activity.