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Related Experiment Video

Updated: Jul 18, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Drug-induced lupus: an update.

¹Division of Rheumatology, Department of Medicine, National University Hospital, Singapore. sheila_vasoo@nuh.com.sg

|December 13, 2006

Summary

Drug-induced lupus erythematosus (DILE) is a lupus-like condition caused by medications. Prompt diagnosis and stopping the offending drug are key for favorable outcomes in most DILE cases.

Area of Science:

Immunology
Pharmacology
Environmental Medicine

Background:

Drug-induced lupus erythematosus (DILE) is a lupus-like syndrome linked to environmental factors.
Over 80 drugs have been associated with DILE since its initial description in 1945.
DILE differs from systemic lupus erythematosus (SLE) in epidemiology and clinical course, with a generally favorable prognosis.

Purpose of the Study:

To review the clinical presentation and diagnosis of DILE.
To update on proposed pathogenic mechanisms of DILE.
To provide an overview of drugs implicated in DILE.

Main Methods:

Literature review of clinical presentations, diagnostic criteria, and pathogenic mechanisms of DILE.
Compilation of a list of drugs known to induce DILE.

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Published on: November 1, 2015

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Last Updated: Jul 18, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Analysis of epidemiological and clinical data from reported DILE cases.

Main Results:

DILE presents as a lupus-like illness with diverse clinical manifestations.
Diagnosis relies on clinical suspicion, serological markers, and exclusion of idiopathic lupus.
Pharmacovigilance is essential for early detection and management.

Conclusions:

Cessation of the offending drug is the primary treatment for DILE.
Understanding pathogenic mechanisms may lead to improved diagnostic and therapeutic strategies.
Ongoing monitoring for DILE is crucial for patient safety and optimal outcomes.