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Updated: Jul 18, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits
Trond Ulven1, Jean-Marie Receveur, Marie Grimstrup
17TM Pharma, Fremtidsvej 3, DK-2970 Hørsholm, Denmark. ulven@chem.sdu.dk
Abstract:
Hits from an in silico derived focused library for CRTH2 were transformed into highly selective antagonists with favorable ADME properties. Oral administration of 4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid (19) inhibited peribronchial eosinophilia and mucus cell hyperplasia in a mouse model of allergic asthma, supporting the therapeutic potential of this novel compound class. In addition, this selective pharmacological tool compound provides further evidence for CRTH2 as a relevant therapeutic target for treatment of Th2- and eosinophil-related inflammation.
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