Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary involvement in systemic sclerosis.

Amira A Shahin1

  • 1Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Treatments in Respiratory Medicine
|December 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetic resonance sialography of the parotid glands in chronic hepatitis C virus patients with and without vasculitis.

International journal of rheumatic diseases·2014
Same author

The effect of leflunomide on the eye dryness in secondary Sjögren's syndrome associated with rheumatoid arthritis and in rheumatoid arthritis patients.

Clinical rheumatology·2014
Same author

Tumor necrosis factor-alpha and neuropsychiatric lupus erythematosus: relation to single photon emission computed tomography findings.

Modern rheumatology·2014
Same author

A retrospective analysis of treatment outcomes in patients with hepatitis C related systemic vasculitis receiving intravenous methylprednisolone and cyclophosphamide.

Clinical rheumatology·2010
Same author

Clinical significance of serum anti-annexin V antibodies in Egyptian patients with scleroderma.

The Egyptian journal of immunology·2010
Same author

Cardiac involvement in patients with systemic lupus erythematosus and correlation of valvular lesions with anti-Ro/SS-A and anti-La/SS-B antibody levels.

Modern rheumatology·2006

Scleroderma (SSc) often causes lung disease, including interstitial fibrosis and pulmonary arterial hypertension (PAH). Early detection and treatment are crucial for managing this multisystem autoimmune disorder.

Area of Science:

  • Rheumatology
  • Pulmonology
  • Radiology

Background:

  • Scleroderma (SSc) is a multisystem autoimmune disorder causing inflammation and fibrosis.
  • Pulmonary involvement in SSc commonly includes interstitial fibrosis and pulmonary arterial hypertension (PAH).
  • Bronchiectasis and pulmonary hemorrhage are rare SSc manifestations.

Purpose of the Study:

  • To review the pulmonary manifestations of SSc.
  • To discuss diagnostic findings, particularly on high-resolution CT.
  • To summarize current therapeutic strategies and outcomes for SSc-related lung disease.

Main Methods:

  • Review of literature on SSc and pulmonary involvement.
  • Analysis of high-resolution CT findings in SSc patients.

Related Experiment Videos

  • Evaluation of treatment efficacy for SSc-related lung diseases.

    • Main Results:

    • High-resolution CT shows interstitial disease in ~90% of SSc patients, often with a subpleural reticular pattern.
    • Distinctive findings include vascular changes in PAH, sometimes without significant fibrosis.
    • Current therapies show limited efficacy, possibly due to late diagnosis.

    Conclusions:

    • Pulmonary involvement is common in SSc, necessitating early clinical awareness.
    • While treatments for SSc-lung disease exist, outcomes vary, and lung transplant is a last resort.
    • Effective management requires prompt diagnosis and intervention.