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Improvement of diastolic filling in hypertensive patients treated with cilazapril
W Haberbosch1, R De Simone, R Dietz
1University Hospital, Giessen, F.R.G.
Insights
Cilazapril treatment significantly improved left ventricular (LV) hypertrophy and diastolic filling patterns in hypertensive patients. These positive effects on cardiac function persisted after one year of therapy.
Area of Science:
- Cardiology
- Pharmacology
- Hypertension Research
Background:
- Essential hypertension is a major risk factor for cardiovascular disease.
- Left ventricular hypertrophy (LVH) is a common adaptation to chronic hypertension.
- Diastolic dysfunction often accompanies LVH and contributes to heart failure.
Purpose of the Study:
- To evaluate the impact of cilazapril on left ventricular (LV) diastolic function.
- To assess changes in cardiac hypertrophy following cilazapril treatment.
- To determine the duration of these effects over a one-year period.
Main Methods:
- A one-year prospective study involving 12 patients with essential hypertension.
- Doppler echocardiography was used to assess LV diastolic filling patterns and cardiac structure.
- Mean arterial pressure (MAP) was monitored over 24 hours.
Main Results:
- Cilazapril treatment led to a significant reduction in LV hypertrophy.
- An improvement in the early (E) and late (A) diastolic filling flow velocities and E/A ratio was observed.
- These beneficial effects on cardiac structure and function were evident after 6 months and sustained at 1 year.
Conclusions:
- Cilazapril effectively reduces left ventricular hypertrophy in hypertensive patients.
- The drug improves diastolic left ventricular filling patterns.
- The positive cardiac remodeling and functional improvements are maintained with long-term cilazapril therapy.
Abstract:
The aim of this study was to assess the behavior of the diastolic left ventricular (LV) filling pattern and cardiac hypertrophy after treatment with cilazapril. Twelve patients (9 male and 3 female) with mild to moderate essential hypertension, aged 46 +/- 14.1 years, were treated with cilazapril for 1 year. They underwent Doppler echocardiography at the beginning (I), after 6 months (II), and after 1 year (III) of treatment. The following parameters were evaluated: mean arterial pressure (MAP) automatically recorded for 24 h, interventricular septal and posterior wall thickness, LV and end-diastolic diameter, LV mass index, early (E) and late (A) diastolic filling flow velocities, and the ratio E/A. A significant reduction in LV hypertrophy and an improved diastolic filling pattern of the left ventricle was shown after 6 months of therapy with cilazapril; this improvement still remained after 1 year of therapy.