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Inflammatory bowel disease is not a risk factor for cardiovascular disease mortality: results from a systematic

Spencer D Dorn1, Robert S Sandler

  • 1Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599-7080, USA.

The American Journal of Gastroenterology
|December 13, 2006
PubMed

Insights

This study found no increased cardiovascular mortality in patients with inflammatory bowel disease (IBD). These findings suggest that IBD does not raise the risk of cardiovascular disease.

Area of Science:

  • Cardiovascular Health
  • Gastroenterology
  • Inflammatory Diseases

Background:

  • Inflammation, particularly C-reactive protein (CRP), is linked to atherosclerosis.
  • Systemic inflammatory diseases are associated with increased cardiovascular (CV) disease risk.

Purpose of the Study:

  • To investigate if inflammatory bowel disease (IBD) is associated with increased CV mortality.
  • To use CV mortality as an indirect measure for CV disease incidence in IBD patients.

Main Methods:

  • A systematic review and meta-analysis of studies published between 1965 and 2006.
  • Included studies reported CV-disease-specific standardized mortality ratios (SMRs) for Crohn's disease (CD) and ulcerative colitis (UC).

Main Results:

  • Eleven studies involving 4,532 CD patients and 9,533 UC patients were analyzed.
  • No statistically significant increase in CV SMR was observed for either CD or UC.
  • Meta-analysis showed a meta-SMR of 1.0 (95% CI 0.8-1.1) for CD and 0.9 (95% CI 0.8-1.0) for UC.

Conclusions:

  • Inflammatory bowel disease (IBD) is not associated with elevated cardiovascular mortality.
  • This suggests an indirect lack of association between IBD and the incidence of cardiovascular disease.
Abstract

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