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Related Experiment Video

Updated: Jul 18, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Tumour lysis syndrome developing during an operation.

M H Lee¹, K I Cheng, R C Jang

¹Department of Paediatrics, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan.

|December 13, 2006

Summary

Surgery can trigger tumour lysis syndrome (TLS) in children with high-grade lymphoma. Anesthetists must monitor for TLS during operative procedures in patients with high tumor burdens.

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Last Updated: Jul 18, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Area of Science:

Oncology
Pediatric Surgery
Critical Care Medicine

Background:

High-grade lymphoma in pediatric patients presents unique management challenges.
Staging laparotomy is a surgical procedure used to determine the extent of lymphoma.
Tumor lysis syndrome (TLS) is a oncologic emergency characterized by metabolic abnormalities.

Observation:

An unusual case of TLS occurred in a child with high-grade lymphoma during a staging laparotomy.
The patient experienced refractory ventricular arrhythmia requiring intensive resuscitation.
Continuous venous-venous hemodialysis was necessary in the intensive care unit.

Findings:

Surgical procedures, such as staging laparotomy, may act as a trigger for TLS development.
High tumor burden in lymphoma patients increases the risk of TLS, especially perioperatively.
Refractory ventricular arrhythmias can be a presenting symptom of TLS in pediatric oncology patients.

Implications:

Anesthetists and surgical teams should maintain a high index of suspicion for TLS in pediatric lymphoma patients undergoing surgery.
Perioperative monitoring and management strategies for TLS should be considered in high-risk surgical oncology cases.
This case highlights the importance of interdisciplinary collaboration in managing complex pediatric oncologic emergencies.