Related Experiment Video
Updated: Jul 18, 2026
Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
Effects of amphetamine and/or L-dopa and physiotherapy after stroke - a blinded randomized study
1Division of Geriatric Medicine, Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Stockholm, Sweden. lars.sonde@sll.se
Objectives:
Major therapeutic advances in the rehabilitation of subacute stroke are lacking. A promising approach is treatment with facilitating drugs like amphetamine or levodopa in combination with physiotherapy.
Methods:
In a randomized, double-blind, placebo-controlled clinical trail, the effect of 10 sessions with either 20 mg of D-amphetamine, 100 mg of L-dopa or 10 mg of D-amphetamine + 50 mg of L-dopa combined with physiotherapy during a 2-week period was investigated in 25 patients admitted to a stroke rehabilitation unit. Motor function (Fugl-Meyer score) and activities of daily living (Barthel's index) were assessed.
Results:
All patients improved significantly over the intervention period. Drug-treated patients did not show any additional increase in motor function or ADL.
Conclusion:
It is feasible and safe to perform larger clinical trials with this type of four-arm design. However, the lack of significant effects could be because of type, dosage, and time of drugs as well as the physical intervention strategy.
