Multistage evaluation of measurement error in a reliability study
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Updated: Jul 18, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Aiyi Liu1, Enrique F Schisterman, Chengqing Wu
1Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, NIH/DHHS, 6100 Executive Boulevard, Rockville, Maryland 20852, USA. liua@mail.nih.gov
Abstract:
We introduce sequential testing procedures for the planning and analysis of reliability studies to assess an exposure's measurement error. The designs allow repeated evaluation of reliability of the measurements and stop testing if early evidence shows the measurement error is within the level of tolerance. Methods are developed and critical values tabulated for a number of two-stage designs. The methods are exemplified using an example evaluating the reliability of biomarkers associated with oxidative stress.
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