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Updated: Jul 18, 2026

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
Published on: May 21, 2018
Transfusion prevents acute chest syndrome predicted by elevated secretory phospholipase A2
Lori A Styles1, Miguel Abboud, Sandra Larkin
1Department of Hematology/Oncology, Children's Hospital and Research Center at Oakland, Oakland, CA 94609, USA. lstyles@mail.cho.org
Abstract:
Acute pulmonary injury is known as acute chest syndrome (ACS) in patients with sickle cell disease (SCD). Secretory phospholipase A2 (sPLA2) was found to predict those at risk for ACS and a trial was designed to determine if red blood cell transfusion can be used to prevent ACS. Patients with an elevated sPLA2 were randomised to either receive a single transfusion or standard care. Five of the eight patients (63%) randomised to standard care developed ACS versus none of the seven patients randomised to the transfusion arm (P = 0.026, Odds ratio = 23.6, 95% confidence interval 1, 557). This study suggests that transfusion may prevent ACS.
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