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DNA repair in aging rat neurons

K Subba Rao1

  • 1ICMR Advanced Center for Research on Aging and Brain, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, Andhra Pradesh 500 046, India. ksrsl@uohyd.ernet.in

Neuroscience
|December 13, 2006
PubMed
Summary

Aging neurons show reduced DNA repair capacity, specifically in base excision repair (BER) and non-homologous end joining (NHEJ) pathways. Deficiencies in DNA polymerase beta and DNA ligase contribute to DNA damage accumulation with age.

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