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Updated: Jul 18, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

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Published on: April 16, 2012

Regulatory T cell maintenance of dominant tolerance: induction of tissue self-defense?

Vanessa Oliveira1, Ana Agua-Doce, Joana Duarte

  • 1Instituto de Medicina Molecular, Universidade de Lisboa, P1694-028 Lisboa, Portugal; Instituto Gulbenkian de Ciência, P2781-901 Oeiras, Portugal.

Transplant Immunology
|December 13, 2006
PubMed

In the last decade there has been an increasing interest for the action of regulatory T cells (Treg) in preventing transplant rejection, autoimmunity and other inflammatory diseases and in maintaining dominant tolerance. It is becoming clear that such regulatory function does not rely simply on direct inhibition of "aggressive" T cells. In fact, several studies suggest that Treg cells may induce changes in the target tissue, promoting a state of "immune privilege" where protective genes such as heme oxygenase-1 (HO-1) and indolamine 2,3 dioxygenase (IDO) may have a critical role.

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