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Updated: Jul 13, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression
Minna-Liisa Ankö1, Maria Ostergård, Minnamaija Lintunen
1Department of Biology, Abo Akademi University, Tykistökatu 6A, 2nd floor, FI-20520 Turku, Finland.
Abstract:
Alternative splicing has an important role in the tissue-specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5' untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat.
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