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Updated: Jul 18, 2026
08:07
Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
Published on: August 2, 2015
UniHI: an entry gate to the human protein interactome
Gautam Chaurasia1, Yasir Iqbal, Christian Hänig
1Institute for Theoretical Biology, Charité, Humboldt-Universität, Berlin, Germany.
Nucleic Acids Research
|December 13, 2006
Summary
Scientists created UniHI, a unified human interactome database, to simplify accessing protein interaction data. This integrated resource combines multiple datasets, aiding biological and medical research by overcoming network inconsistencies.
Area of Science:
- Functional genomics
- Systems biology
- Bioinformatics
Background:
- Systematic mapping of protein-protein interactions is crucial for functional genomics.
- Existing human interactome datasets show limited overlap, hindering research usability.
- Researchers need a unified resource to access diverse protein interaction data.
Purpose of the Study:
- To integrate available human protein interaction data into a single, accessible online database.
- To provide a unified entry point for exploring the human interactome.
- To facilitate the identification of protein interaction partners.
Main Methods:
- Integration of 10 major human interaction maps.
- Data derived from both computational and experimental methods.
- Development of the UniHI (Unified Human Interactome) online database.
Main Results:
- UniHI integrates over 150,000 distinct protein-protein interactions.
- The database includes more than 17,000 unique human proteins.
- Provides a flexible and comprehensive tool for interactome analysis.
Conclusions:
- UniHI offers a centralized solution for accessing heterogeneous human interactome data.
- The database enhances usability for researchers in biology and medicine.
- Facilitates a more efficient exploration of protein interaction networks.
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These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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These groups modify specific amino acids in a protein.
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