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Poststroke memory function in nondemented patients: a systematic review on frequency and neuroimaging correlates
Liselore Snaphaan1, Frank-Erik de Leeuw
1Department of Neurology, University Medical Center St. Radboud, PO Box 9101, 6500 HB Nijmegen, (HP 935), The Netherlands.
Stroke
|December 13, 2006
Summary
Memory problems after stroke may improve over time. Some stroke survivors initially diagnosed with poststroke dementia may no longer meet criteria a year later, suggesting potential reversibility.
Area of Science:
- Neurology
- Cognitive Science
Background:
- Poststroke memory dysfunction is key for diagnosing poststroke dementia.
- The course of poststroke memory function is often assumed to be stable.
- Evidence suggests poststroke memory function may be reversible.
Purpose of the Study:
- Systematically review the time course of poststroke memory function in non-demented stroke survivors.
- Investigate (pre-)stroke characteristics influencing poststroke memory function.
Main Methods:
- Systematic literature search of PubMed using "memory" and "stroke" as keywords.
- Included 65 articles from an initial search of 798.
- Extracted data from selected studies.
Main Results:
- Prevalence of poststroke memory dysfunction decreased from 23-55% at 3 months to 11-31% at 1 year.
- Larger stroke volume, prestroke medial temporal lobe atrophy, and white matter lesions correlated with poorer memory function.
- Five studies reported prevalence at different poststroke intervals.
Conclusions:
- Poststroke dementia may be reversible in a significant number of patients.
- Memory dysfunction at 3 months poststroke does not always persist at 1 year.
- Standardized cognitive reassessment is recommended for patients diagnosed with poststroke dementia.

