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Updated: Jul 18, 2026
12:55
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
Chemotherapy for advanced germ cell tumors
G Varuni Kondagunta1, Robert J Motzer
1Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center,New York, NY 10021, USA. kondaguv@mskcc.org
Summary
Germ cell tumors are highly curable cancers. Treatment decisions for patients are guided by prognostic criteria and risk-directed chemotherapy, ensuring effective management even for resistant cases.
Area of Science:
- Oncology
- Cancer Therapeutics
- Clinical Trials
Background:
- Germ cell tumors are among the most curable cancers.
- Treatment strategies have evolved through clinical trials and prognostic factor analysis.
Purpose of the Study:
- To review prognostic criteria for germ cell tumor treatment decisions.
- To outline current therapeutic approaches for germ cell tumors.
Main Methods:
- Review of randomized and nonrandomized trials for first-line, salvage, and palliative therapy.
- Application of the International Germ Cell Cancer Collaborative Group model for risk-directed chemotherapy.
- Evaluation of the role of surgery post-chemotherapy.
Main Results:
- Standard therapy (etoposide/cisplatin or BEP x 3) cures ~90% of good-risk patients.
- BEP x 4 achieves durable complete response in 75% of intermediate-risk and 45% of poor-risk patients.
- Salvage options include ifosfamide/cisplatin or high-dose carboplatin with stem-cell rescue; surgery is crucial.
Conclusions:
- Curative treatments are available for germ cell tumors, including resistant cases.
- Treatment selection relies on established clinical criteria.
- Serum tumor markers and post-chemotherapy surgery are vital for management.
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