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Oxidant and non-enzymatic antioxidant status in measles

Mustafa Cemek1, Semiha Dede, Fahri Bayiroglu

  • 1Department of Chemistry (Biochemistry Division), Faculty of Science and Arts, Afyon Kocatepe University, Afyon, Turkey. mcemek@yahoo.com

Journal of Tropical Pediatrics
|December 13, 2006
PubMed

Insights

Children with measles show altered oxidant and antioxidant levels, with decreased non-enzymatic antioxidants and increased lipid peroxidation. This study investigates malondialdehyde (MDA), reduced glutathione (GSH), and vitamin C in measles patients.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Biochemistry

Background:

  • Measles is a highly contagious childhood viral illness with severe complications, morbidity, and mortality.
  • Oxidative stress plays a role in various diseases, but its impact on measles is not well-understood.
  • Specific data on non-enzymatic antioxidant levels in children with measles are lacking.

Purpose of the Study:

  • To investigate antioxidant and oxidant status in children diagnosed with measles.
  • To evaluate changes in non-enzymatic antioxidant levels and their relationship to oxidative stress in measles.
  • To measure blood levels of malondialdehyde (MDA), reduced glutathione (GSH), and vitamin C in measles patients.

Main Methods:

  • Measurement of whole blood malondialdehyde (MDA) as a marker of lipid peroxidation.
  • Quantification of whole blood reduced glutathione (GSH) levels.
  • Assay of serum beta-carotene, retinol, alpha-tocopherol, and ascorbic acid (vitamin C).

Main Results:

  • Statistically significant differences (p < 0.05) were observed for all measured parameters between study and control groups.
  • Children with measles exhibited decreased non-enzymatic antioxidant status.
  • Increased lipid peroxidation, indicated by elevated MDA levels, was observed in the measles group.

Conclusions:

  • The findings suggest an alteration in the oxidant-antioxidant defense system in children suffering from measles.
  • Measles infection is associated with both reduced antioxidant capacity and increased oxidative stress.

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