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Proposed standard nomenclature for the alpha- and beta-globin gene families
Gabriela Aguileta1, Joseph P Bielawski, Ziheng Yang
1Department of Biology, University College London, London, England. gabriela.aguileta@lcb.uu.se
Abstract:
The globin family of genes and proteins has been a recurrent object of study for many decades. This interest has generated a vast amount of knowledge. However it has also created an inconsistent and confusing nomenclature, due to the lack of a systematic approach to naming genes and failure to reflect the phylogenetic relationships among genes of the gene family. To alleviate the problems with the existing system, here we propose a standardized nomenclature for the alpha and beta globin family of genes, based on a phylogenetic analysis of vertebrate alpha and beta globins, and following the Guidelines for Human Gene Nomenclature.
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