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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Serum prostate-specific antigen levels in Middle Eastern men with subclinical prostatitis
J T Anim1, E O Kehinde, M A Sheikh
1Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait. anim@hsc.edu.kw
Summary
Subclinical prostatitis significantly elevates serum prostate-specific antigen (PSA) in over 40% of Kuwaiti men, potentially impacting prostate cancer screening. Local factors necessitate a tailored approach for accurate prostate cancer detection.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Prostate-specific antigen (PSA) is a key biomarker for prostate cancer screening.
- Inflammation of the prostate (prostatitis) can affect PSA levels.
- Understanding local factors influencing PSA is crucial for accurate diagnosis.
Purpose of the Study:
- To determine the impact of prostatitis on serum PSA levels in patients undergoing prostate disease investigation in Kuwait.
- To assess the prevalence of prostatitis in benign and malignant prostate conditions.
Main Methods:
- Serum PSA levels were measured in 270 men investigated for prostatic disease.
- Prostate tissue specimens (331) were histologically evaluated for prostatitis.
- The association between prostatitis, prostate disease type, and PSA levels was analyzed.
Main Results:
- Prostatitis was present in 70.4% of benign and 24.2% of malignant prostate disease cases.
- Over 40% of men with benign prostate disease and prostatitis had PSA levels >10 ng/ml.
- 76% of men with malignant prostate disease and prostatitis also had elevated PSA levels (>10 ng/ml).
Conclusions:
- Subclinical prostatitis is a significant contributor to elevated serum PSA in Kuwait, affecting over 40% of men.
- Elevated PSA levels due to prostatitis can complicate prostate cancer screening.
- A localized screening strategy may be required to improve prostate cancer detection accuracy in Kuwait.
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