Related Experiment Video
Updated: Jul 18, 2026

Investigating Flagella-Driven Motility in Escherichia coli by Applying Three Established Techniques in a Series
Published on: May 10, 2020
Waltzing transporters and 'the dance macabre' between humans and bacteria
Olga Lomovskaya1, Helen I Zgurskaya, Maxim Totrov
1Mpex Pharmaceuticals, Inc. 3030 Bunker Hill Street, Suite 200 San Diego, California 92109, USA. olomovskaya@mpexpharma.com
Abstract:
Multidrug-resistance efflux pumps - in particular those belonging to the resistance-nodulation-cell-division (RND) family of transporters, with their unusually high degree of substrate promiscuity - significantly restrict the effectiveness of antibacterial therapy. Recent years have heralded remarkable insights into the structure and mechanisms of these fascinating molecular machines. Here, we review recent advances in the field and describe various approaches used in combating efflux-mediated resistance.
Related Concept Videos
Intracellular Movement of Viruses and Bacteria
Colonisation of Pathogens
Microbial Interactions: Cooperation
Coordination of Gene Expression Processes in Bacteria
Chemotaxis in E. coli
Bacterial Translocation and Protein Secretion

