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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Related Experiment Video

Updated: Jul 18, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Who puts the tubercle in tuberculosis?

David G Russell1

  • 1Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA. dgr8@cornell.edu

Nature Reviews. Microbiology
|December 13, 2006
PubMed
Summary

Tuberculosis (TB) granulomas contain Mycobacterium tuberculosis, preventing disease. This review explores how TB bacilli influence granuloma formation and maintenance, impacting disease spread.

Area of Science:

  • Immunology
  • Microbiology
  • Pathology

Background:

  • Tuberculosis (TB) is a major global health threat, infecting one-third of the world's population and causing millions of deaths annually.
  • The immune system contains Mycobacterium tuberculosis within granulomas, preventing widespread disease in most infected individuals.
  • The precise role of Mycobacterium tuberculosis in granuloma development and persistence remains incompletely understood.

Purpose of the Study:

  • To investigate how Mycobacterium tuberculosis influences the formation and maintenance of granulomas.
  • To elucidate the mechanisms by which the TB bacillus impacts granuloma structure and function.
  • To understand how granuloma dynamics contribute to the dissemination of tuberculosis.

Main Methods:

  • This review synthesizes current research on the host-pathogen interactions within TB granulomas.

Related Experiment Videos

Last Updated: Jul 18, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

  • It examines studies investigating the molecular and cellular processes involved in granuloma formation and maintenance.
  • The review considers evidence on how Mycobacterium tuberculosis actively manipulates the granuloma environment.

    • Main Results:

    • Mycobacterium tuberculosis actively shapes granuloma formation and stability.
    • The bacillus employs strategies to survive and persist within the granuloma.
    • Granuloma integrity is crucial for controlling, but also potentially facilitating, TB spread.

    Conclusions:

    • Understanding Mycobacterium tuberculosis's influence on granuloma biology is key to developing effective TB control strategies.
    • Targeting host-pathogen interactions within granulomas may offer new therapeutic avenues.
    • Further research into granuloma dynamics is essential for combating tuberculosis transmission.