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[Ischemic ulcers in systemic connective tissue disorders]

Jan Tore Gran1, Øyvind Midtvedt

  • 1Revmatologisk avdeling Rikshospitalet-Radiumhospitalet 0027 Oslo. jan.tore.gran@rikshospitalet.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|December 13, 2006
PubMed

Insights

Digital ulcers, often seen in systemic sclerosis, require excluding non-rheumatic causes. Treatment involves pain relief, preventing cold exposure, antibiotics for infection, and potential therapies like vasodilators or sympathectomy.

Area of Science:

  • Rheumatology
  • Vascular Medicine
  • Dermatology

Context:

  • Digital ulcers are a common complication in systemic connective tissue disorders.
  • Systemic sclerosis affects up to 40% of patients with digital ulcers.
  • Understanding the etiology of digital ulcers is crucial for effective management.

Purpose:

  • To review the current understanding of digital ulcers in systemic connective tissue disorders.
  • To outline diagnostic considerations, particularly excluding non-rheumatic causes.
  • To summarize established and emerging treatment strategies for digital ulcers.

Summary:

  • Digital ulcers are prevalent in systemic sclerosis, necessitating differentiation from other circulatory issues.
  • Initial management includes analgesia, cold prevention, and antibiotics for infections.
  • Pharmacological interventions such as vasodilators, prostacyclin analogues, endothelin receptor antagonists, and sildenafil are discussed.
  • Surgical or chemical sympathectomy represents another therapeutic option.

Impact:

  • Provides a comprehensive overview for clinicians managing patients with digital ulcers.
  • Highlights the importance of a differential diagnosis in cases of compromised blood circulation.
  • Informs treatment decisions by presenting a range of therapeutic options for digital ulcers.
Abstract

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