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[Laboratory evolutive aspects of children under paracoccidioidomycosis treatment]

Maria Gorete dos Santos Nogueira1, Gláucia Manzan Queiroz Andrade, Edward Tonelli

  • 1Hospital das Clinicas, Faculdade de Medicina, Universidade Federal do Estado de Minas Gerais, Belo Horizonte, MG. dagor@uol.com.br

Revista Da Sociedade Brasileira De Medicina Tropical
|December 13, 2006
PubMed

Insights

Monitoring paracoccidioidomycosis in children requires long-term treatment. Key laboratory markers normalize over time, aiding early and sustained therapeutic response assessment.

Area of Science:

  • Pediatric Infectious Diseases
  • Mycology
  • Clinical Laboratory Science

Context:

  • Paracoccidioidomycosis (PCM) is a significant fungal infection in children.
  • Treatment duration and monitoring strategies for pediatric PCM require further elucidation.
  • This study evaluates laboratory markers for assessing treatment response in children with PCM.

Purpose:

  • To analyze laboratory data in children with paracoccidioidomycosis (PCM) during long-term treatment.
  • To identify laboratory markers indicative of early and sustained therapeutic response in pediatric PCM.
  • To establish the utility of laboratory parameters for monitoring the complete treatment course of pediatric PCM.

Summary:

  • Laboratory data from 38 children with paracoccidioidomycosis, treated for 24-30 months with various antifungals, were analyzed.
  • Anemia, eosinophilia, elevated bilirubin/aminotransferases normalized within 3 months; hypoalbuminemia normalized within 6 months.
  • Peripheral leukocytes, ESR, IgG, and anti-Paracoccidioides titers normalized within 9-12 months, indicating long-term monitoring utility.

Impact:

  • Identifies specific laboratory markers for monitoring early and long-term treatment response in pediatric paracoccidioidomycosis.
  • Highlights the necessity of extended treatment durations for achieving sustained remission in pediatric PCM.
  • Provides valuable insights for clinicians managing pediatric fungal infections, improving patient outcomes through informed monitoring.

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