Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prolyl endopeptidases.

J Gass1, C Khosla

  • 1Department of Chemical Engineering, Stanford University, Stanford, California 94305, USA.

Cellular and Molecular Life Sciences : CMLS
|December 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Body mass index (BMI), postoperative appearance satisfaction, and sexual function in breast cancer survivorship.

Journal of cancer survivorship : research and practice·2017
Same author

The clinical heterogeneity of late-onset MELAS.

Molecular genetics and metabolism reports·2017
Same author

The impact of mastectomy type on the Female Sexual Function Index (FSFI), satisfaction with appearance, and the reconstructed breast's role in intimacy.

Breast cancer research and treatment·2017
Same author

Late-onset mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS), defining symptomology.

Molecular genetics and metabolism reports·2017
Same author

Novel therapies for coeliac disease.

Journal of internal medicine·2011
Same author

Static and dynamic magnetic properties of Co nanoparticles.

Journal of nanoscience and nanotechnology·2008
Same journal

Single-Cell dissection of fibrodysplasia ossificans progressiva identifies SPP1 as a mediator of macrophage-fibroadipogenic progenitors crosstalk.

Cellular and molecular life sciences : CMLS·2026
Same journal

Ablation of the renal tubular gluconeogenic enzyme PCK1 drives AKI-to-CKD transition by negatively regulating the TGF-β/Smad3 signaling pathway.

Cellular and molecular life sciences : CMLS·2026
Same journal

LncRNA modulates Dpp-mediated wing development to influence flight in Aedes aegypti.

Cellular and molecular life sciences : CMLS·2026
Same journal

TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis.

Cellular and molecular life sciences : CMLS·2026
Same journal

PRMT5-Cacna1d axis maintains calcium homeostasis to regulate postnatal motor development in mice.

Cellular and molecular life sciences : CMLS·2026
Same journal

Advances and clinical potential of epigenome editing.

Cellular and molecular life sciences : CMLS·2026
See all related articles

Prolyl endopeptidase (PEP) enzymes, crucial for cleaving proline-rich peptides, are explored as drug targets. Their structure, function, and therapeutic potential for neurological diseases and celiac sprue are reviewed.

Area of Science:

  • Biochemistry
  • Enzymology
  • Drug Discovery

Background:

  • Prolyl endopeptidase (PEP) enzymes are proteases that cleave peptide bonds at proline residues.
  • The well-studied PEP family features a unique seven-blade beta-propeller domain and a catalytic domain.
  • Other structurally distinct PEPs exist but are less understood.

Purpose of the Study:

  • To review the structure and function of prolyl endopeptidase (PEP) enzymes.
  • To explore the evaluation of PEPs as drug targets and therapeutic agents.
  • To highlight the potential of PEPs in treating neurological diseases and celiac sprue.

Main Methods:

  • Structural and functional studies of PEP enzymes.
  • In vitro analysis of neuropeptide cleavage by human PEP.

Related Experiment Videos

  • Evaluation of microbial PEPs for therapeutic applications.

    • Main Results:

    • Elucidation of the peptide entry mechanism in the two-domain PEP structure.
    • Human PEP's ability to cleave neuropeptides in vitro suggests neurological applications.
    • Microbial PEPs show promise for treating celiac sprue by degrading gluten peptides.

    Conclusions:

    • Prolyl endopeptidase enzymes represent a significant area for therapeutic development.
    • Targeting PEPs offers potential treatments for neurological disorders and inflammatory conditions like celiac sprue.
    • Further research into diverse PEP families could uncover novel therapeutic strategies.