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Updated: Jul 18, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
[The morphologic variants of KSHV/HHV 8-associated lymphoproliferations]
C Loddenkemper1, T Longerich, T Schneider
1Institut für Pathologie, Konsultations- und Referenzzentrum für Lymphknoten- und Hämatopathologie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin. christoph.loddenkemper@charite.de
Abstract:
KSHV/HHV 8 infection is associated with primary effusion lymphoma, multicentric Castleman disease (MCD) and MCD-associated plasmablastic lymphoma. We report the case of an HIV-infected male with Kaposi sarcoma, MCD in the lymph node and development of a KSHV/HHV 8-associated plasmablastic lymphoma in the liver. Immunohistochemistry revealed an HHV 8 infection of plasmablasts showing cytoplasmic IgM/lambda expression. To the best of our knowledge, liver infiltration by a MCD-associated HHV 8 positive plasmablastic lymphoma has not been documented previously. The differential diagnosis is discussed.
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