[Dyslipidemia and schizophrenia]
Related Experiment Video
Updated: Jun 25, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Tilman Wetterling1, Barbara Schneider, Bernhard Weber
1Klinik für Psychiatrie und Psychotherapie, J.-W.-Goethe-Universität, Frankfurt/M. tilman.wetterling@vivantes.de
Objective:
There is some evidence that the treatment with new ("atypical") neuroleptics is associated with a higher frequency of hyperlipidemia.
Aim:
In this study the serum lipid levels of patients with chronic schizophrenia were investigated.
Methods:
The serum lipid levels of 177 consecutively admitted schizophrenic patients treated at least 5 years were evaluated.
Results:
No gender differences of lipid concentrations could be detected. A considerable rate of the patients (35.6 %) showed elevated triglycerides (> 150 mg/dl) or elevated cholesterol levels (> 200 mg/dl; 43.9 %). The rate of patients with elevated cholesterol or triglyceride concentrations is associated with the duration of treatment. The comparison of different groups of neuroleptics yielded at best a trend to higher triglyceride levels in the patients treated with dibenzodiazepines compared to those receiving only classical neuroleptics. The triglyceride concentrations correlated with the body mass index (rho = 0.25, p < 0.01).
Conclusions:
This study revealed evidence for an association of the rate of patients with elevated lipid levels and duration of neuroleptic treatment in schizophrenia patients.
More Related Videos
08:04Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
Published on: November 19, 2020
05:14Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
Published on: September 8, 2021
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Psychosis and Antipsychotic Drugs: Overview
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Schizophrenia
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia