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Updated: Jul 18, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
Published on: May 15, 2020
[Rofecoxib-induced psychosis]
Michael Sabolek1, Alexander Unrath, Anne-Dorte Sperfeld
1Neurologische Klinik der Universität Ulm (Direktor: Prof. Dr. med. A. C. Ludolph). michael.sabolek@uni-ulm.de
Abstract:
Acute psychosis is a possible side effect of many centrally acting drugs. Its appearance is facilitated by certain conditions like advanced age, comedication, or comorbidity. We report two cases of acute psychotic syndromes with visual (Case 1 + 2) and auditory (Case 1) hallucinations under rofecoxib, a cyclooxygenase-2-inhibitor. This is one of the first reports of psychotic disorders under rofecoxib intake. We present a review of the literature on mental side effects of NSAID and on the pharmacological basis of the association of cyclooxygenase-inhibitors and mental disorders.
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