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Related Experiment Video

Updated: Jul 18, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

[Rofecoxib-induced psychosis].

Michael Sabolek¹, Alexander Unrath, Anne-Dorte Sperfeld

¹Neurologische Klinik der Universität Ulm (Direktor: Prof. Dr. med. A. C. Ludolph). michael.sabolek@uni-ulm.de

Psychiatrische Praxis

|December 13, 2006

Summary

Acute psychosis, including hallucinations, can be a side effect of drugs like rofecoxib, a cyclooxygenase-2 inhibitor. This report highlights two cases and reviews NSAID-induced mental side effects.

Related Experiment Videos

Last Updated: Jul 18, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Acute psychosis is a known adverse effect of various centrally acting medications.
Factors such as advanced age, comedication, and comorbidity can increase the risk of drug-induced psychosis.
Nonsteroidal anti-inflammatory drugs (NSAIDs) can potentially cause central nervous system side effects.

Observation:

Two cases of acute psychotic syndromes are presented, characterized by visual hallucinations in both patients and auditory hallucinations in one.
These psychotic symptoms emerged during the intake of rofecoxib, a selective cyclooxygenase-2 inhibitor.
This represents one of the initial documented instances of psychotic disorders associated with rofecoxib use.

Findings:

Rofecoxib, a cyclooxygenase-2 inhibitor, was associated with the development of acute psychotic syndromes, including hallucinations.
The literature review indicates a potential link between NSAIDs and mental disturbances.
Pharmacological mechanisms underlying the association between cyclooxygenase-inhibitors and psychiatric disorders are discussed.

Implications:

Clinicians should consider the potential for neuropsychiatric side effects, such as psychosis, with cyclooxygenase-2 inhibitors like rofecoxib.
Awareness of these adverse events is crucial for accurate diagnosis and patient management.
Further research into the neurobiological pathways connecting NSAIDs and mental health is warranted.