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Related Experiment Videos

Blood conservation techniques and platelet function in cardiac surgery.

J Boldt1, B Zickmann, A Czeke

  • 1Department of Anesthesiology and Intensive Care Medicine, Justus-Liebig-University Giessen, Federal Republic of Germany.

Anesthesiology
|September 1, 1991
PubMed
Summary
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Cardiopulmonary bypass (CPB) impairs platelet aggregation. Cell separators significantly reduced platelet function post-surgery, while hemofiltration and aprotinin treatments allowed for platelet function normalization.

Area of Science:

  • Cardiovascular Surgery
  • Hematology
  • Anesthesiology

Background:

  • Postoperative alterations in platelet function are a significant concern following cardiopulmonary bypass (CPB).
  • Understanding the impact of blood conservation techniques on platelet aggregation is crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the effect of three blood conservation techniques on platelet aggregation after CPB.
  • To compare the efficacy of cell separators, hemofiltration, and high-dose aprotinin in preserving platelet function.

Main Methods:

  • A randomized study involving 30 patients undergoing aortocoronary bypass grafting.
  • Patients were divided into three groups: cell separator, hemofiltration, and high-dose aprotinin.
  • Platelet aggregation was measured using turbidimetric methods with adenosine diphosphate, collagen, and epinephrine as agonists.

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Main Results:

  • Platelet aggregation was significantly reduced in the cell separator group post-CPB.
  • Platelet function normalized by the first postoperative day in patients treated with hemofiltration or aprotinin.
  • Blood loss was highest in the cell separator group compared to the other two groups.

Conclusions:

  • Cell separators significantly impair platelet aggregation after CPB.
  • Hemofiltration and high-dose aprotinin are effective in preserving platelet function post-CPB.
  • Both hemofiltration and aprotinin demonstrate comparable efficacy in managing blood loss and maintaining platelet function.