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Updated: Jul 18, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
Published on: September 20, 2024
[Refractory epilepsy as the presenting symptom of a brucellar brain abscess]
R Carrasco-Moro1, E García-Navarrete, M Pedrosa-Sánchez
1Servicio de Neurocirugía, Hospital Universitario de la Princesa, 28006 Madrid, España. rocamo@gmail.com
Introduction:
Brucellosis is a zoonotic disease that is occasionally transmitted to human beings from infected animal reservoirs. It is an important condition in endemic areas. One infrequent complication of systemic brucellosis is the infection of the central or the peripheral nervous systems.
Case Report:
A 54-year-old male who was being studied prior to surgery for refractory epilepsy, with clinical expression in the form of complex partial seizures. Neuroimaging findings revealed an expansive lesion in the right temporal lobe, which direct serological, histopathological and microbiological evidence showed to be a chronic brucellar abscess. After combined treatment involving complete surgical resection followed by a cycle of standard antimicrobial therapy, the patient was seizure-free at one year of follow-up.
Conclusions:
Despite its low frequency, infection by Brucella must be considered in the differential diagnosis of intracranial expansive lesions, as well as in the case of patients whose presenting symptoms are epileptic seizures. To perform the diagnosis it is especially important to be aware of the wide range of clinical and radiological manifestations that can be produced, and which do not always correlate. Identification of risk factors on the patient record is also a crucial step.
Insights
Brucellosis can cause rare brain abscesses, leading to epilepsy. Early diagnosis and treatment, including surgery and antibiotics, can resolve these neurological complications.
Area of Science:
- Neurology
- Infectious Diseases
- Neurosurgery
Background:
- Brucellosis is a zoonotic disease with potential for rare central nervous system complications.
- Intracranial brucellar abscesses are infrequent but significant neurological manifestations.
Observation:
- A 54-year-old male presented with refractory epilepsy and a temporal lobe lesion.
- Neuroimaging revealed an expansive lesion later confirmed as a chronic brucellar abscess.
Findings:
- Complete surgical resection and antimicrobial therapy led to seizure freedom at one-year follow-up.
- Diagnosis required serological, histopathological, and microbiological evidence.
Implications:
- Brucella infection should be considered in the differential diagnosis of intracranial expansive lesions and epileptic seizures.
- Awareness of diverse clinical and radiological presentations is crucial for diagnosis.
- Identifying patient risk factors aids in diagnosing neurobrucellosis.
Related Concept Videos
Brain Abscess l: Introduction
Encephalitis l: Introduction
Seizures l: Introduction
Epilepsy ll: Types
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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