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Related Experiment Videos

New methods for hemoglobin detection in a microparticle-plasma suspension.

M Brandl1, J Hartmann, D Falkenhagen

  • 1Center for Biomedical Technology, Danube University Krems, Krems, Austria. martin.brandl@donau-uni.ac.at

The International Journal of Artificial Organs
|December 13, 2006
PubMed
Summary

A novel flow-dynamic filter system detects free hemoglobin (fHb) in extracorporeal blood purification systems. This system ensures patient safety by monitoring filtration and preventing damage during Microspheres based Detoxification System (MDS) operation.

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Area of Science:

  • Biomedical Engineering
  • Medical Device Technology
  • Blood Purification

Background:

  • Microspheres based Detoxification System (MDS) uses micro-adsorbent particles for blood purification.
  • Hollow fiber plasma filters in MDS can be damaged, releasing free hemoglobin (fHb).
  • Detecting fHb is crucial for patient safety in extracorporeal circuits.

Purpose of the Study:

  • To design and evaluate a flow-dynamic filter system for continuous microparticle separation.
  • To enable optical detection of free hemoglobin (fHb) in the MDS filtrate.
  • To implement a fail-safe mechanism for fHb detection and system monitoring.

Main Methods:

  • A flow-dynamic filter utilizing a liquid vortex for microparticle separation.
  • Use of 3 and 8 micron cellulose nitrate filter membranes.

Related Experiment Videos

  • Optical detection of fHb with a sensitivity of 0.15 g/dL.
  • A clamp-based system to monitor bypass filtrate flow and detect membrane occlusion.

    • Main Results:

    • Achieved particle-free bypass filtrate flow rates of 0.5 and 0.8 ml/min.
    • Demonstrated reliable optical detection of fHb.
    • Validated a fail-safe mechanism for monitoring filtration rate and system shutdown.

    Conclusions:

    • The developed flow-dynamic filter system effectively separates microparticles and enables fHb detection.
    • The integrated safety mechanism ensures medical regulatory compliance.
    • This technology enhances the safety and reliability of MDS blood purification.