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Updated: Jul 18, 2026

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
Published on: August 29, 2017
Anti-influenza virus agents: synthesis and mode of action
Irene M Lagoja1, Erik De Clercq
1Laboratory of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Abstract:
Annual epidemics of influenza virus infection are responsible for considerable morbidity and mortality, and pandemics are much more devastating. Considerable knowledge of viral infectivity and replication has been acquired, but many details still have to be elucidated and the virus remains a challenging target for drug design and development. This review provides an overview of the antiviral drugs targeting the influenza viral replicative cycle. Included are a brief description of their chemical syntheses and biological activities. For other reviews, see References1-9.
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