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Related Experiment Videos

Vitamin D resistance.

Roger Bouillon1, Annemieke Verstuyf, Chantal Mathieu

  • 1Laboratory for Experimental Medicine and Endocrinology, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, bus 902, B-3000 Leuven, Belgium. Roger.Bouillon@med.kuleuven.be

Best Practice & Research. Clinical Endocrinology & Metabolism
|December 13, 2006
PubMed
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Vitamin D, through its receptor (VDR), regulates calcium and impacts numerous systems beyond bone health. VDR deficiency, not vitamin D deficiency, causes hair loss, highlighting VDR

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • Vitamin D is synthesized in skin or obtained from diet.
  • It undergoes hydroxylation to 1,25-(OH)2 vitamin D.
  • This active form binds the vitamin D receptor (VDR), a nuclear transcription factor.

Purpose of the Study:

  • To explore the multifaceted roles of the vitamin D-VDR system.
  • To understand its effects beyond calcium homeostasis.
  • To investigate VDR's ligand-dependent and independent actions.

Main Methods:

  • Utilized VDR-deficient mice models.
  • Analyzed gene expression regulated by VDR.
  • Studied VDR's role in cellular proliferation and differentiation.

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Main Results:

  • VDR regulates intestinal calcium transport (TRPV6) and bone cell function.
  • VDR is crucial for hair cycle maintenance (ligand-independent).
  • VDR influences cell cycle, hypertension, cardiac function, and immune responses.

Conclusions:

  • The vitamin D endocrine system has broad systemic effects.
  • VDR plays critical roles in gene regulation and cellular processes.
  • VDR actions extend to skin, cardiovascular, and immune systems.