Control of proliferation by myeloid growth factors

At present the molecular events which regulate the proliferation and developmental fates of haemopoietic cells are poorly understood. Until recently, the only receptor for the myeloid growth factors which had been characterized extensively was that for M-CSF (c-fms). The molecular cloning of receptors for IL-3, GM-CSF and G-CSF should now permit rapid progress in the analysis of receptor-mediated haemopoietic cell differentiation and development, and should also reveal how the process of leukaemic transformation effects these events.