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Related Experiment Videos

Aripiprazole and delirium.

Adekola O Alao1, Lindsay Moskowitz

  • 1SUNY Upstate Medical University, Syracuse, NY, USA. Alaoa@upstate.edu

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
|December 13, 2006
PubMed
Summary
This summary is machine-generated.

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Aripiprazole effectively treated delirium, improving patient confusion and agitation within seven days. This study highlights aripiprazole as a potential treatment for delirium, warranting further investigation.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Delirium is a prevalent psychiatric condition, particularly in medically compromised patients, indicating severe illness and leading to increased morbidity and mortality.
  • Traditional treatments for delirium-associated agitation often involve haloperidol, but atypical antipsychotics are increasingly considered.
  • Consultation-liaison psychiatry frequently encounters delirium, a condition associated with adverse patient outcomes and prolonged hospital stays.

Observation:

  • Two case studies explored the efficacy of aripiprazole in treating delirium.
  • Patients received either 30 mg or 15 mg of aripiprazole.
  • Improvement was assessed using the Mini-Mental Status Exam (MMSE) and Delirium Rating Scale (DRS).

Findings:

  • Both patients exhibited significant improvement in confusion, disorientation, and agitation within seven days of aripiprazole treatment.

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  • In the first case, MMSE scores rose from 5 to 28, and DRS scores decreased from 28 to 6.
  • In the second case, MMSE scores improved from 7 to 27, with DRS scores declining from 18 to 6.

    • Implications:

    • This report presents the initial findings on aripiprazole's successful use in treating delirium.
    • The positive outcomes suggest aripiprazole may be a viable therapeutic option for delirium management.
    • Further research is recommended to validate these findings and establish aripiprazole's role in delirium treatment protocols.