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Related Experiment Video

Updated: Jul 18, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

Aripiprazole and delirium.

Adekola O Alao¹, Lindsay Moskowitz

¹SUNY Upstate Medical University, Syracuse, NY, USA. Alaoa@upstate.edu

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists

|December 13, 2006

Summary

Aripiprazole effectively treated delirium, improving patient confusion and agitation within seven days. This study highlights aripiprazole as a potential treatment for delirium, warranting further investigation.

Area of Science:

Psychiatry
Pharmacology

Background:

Delirium is a prevalent psychiatric condition, particularly in medically compromised patients, indicating severe illness and leading to increased morbidity and mortality.
Traditional treatments for delirium-associated agitation often involve haloperidol, but atypical antipsychotics are increasingly considered.
Consultation-liaison psychiatry frequently encounters delirium, a condition associated with adverse patient outcomes and prolonged hospital stays.

Observation:

Two case studies explored the efficacy of aripiprazole in treating delirium.
Patients received either 30 mg or 15 mg of aripiprazole.
Improvement was assessed using the Mini-Mental Status Exam (MMSE) and Delirium Rating Scale (DRS).

Findings:

Both patients exhibited significant improvement in confusion, disorientation, and agitation within seven days of aripiprazole treatment.

Related Experiment Videos

Last Updated: Jul 18, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

In the first case, MMSE scores rose from 5 to 28, and DRS scores decreased from 28 to 6.

In the second case, MMSE scores improved from 7 to 27, with DRS scores declining from 18 to 6.

Implications:

This report presents the initial findings on aripiprazole's successful use in treating delirium.
The positive outcomes suggest aripiprazole may be a viable therapeutic option for delirium management.
Further research is recommended to validate these findings and establish aripiprazole's role in delirium treatment protocols.