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Androgen receptor coregulators and their involvement in the development and progression of prostate cancer

Renée Chmelar1, Grant Buchanan, Eleanor F Need

  • 1Department of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

International Journal of Cancer
|December 14, 2006
PubMed

Insights

The androgen receptor (AR) signaling pathway is crucial for prostate health but its role in prostate cancer progression is unclear. This review examines how AR deregulation drives cancer growth and spread by altering target gene expression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Urology

Background:

  • The androgen receptor (AR) signaling axis is vital for male urogenital development and prostate function.
  • While AR's role in prostate health is established, its precise contribution to prostate cancer initiation, progression, and metastasis remains incompletely understood.
  • Aberrant molecular events affecting the AR, including altered expression, mutations, and post-translational modifications, are implicated in prostate cancer's natural history.

Purpose of the Study:

  • To review the evidence linking deregulated androgen receptor expression and function to prostate cancer progression.
  • To explore how alterations in AR and its associated coactivators/corepressors influence prostate cancer development.
  • To elucidate the mechanisms by which AR pathway dysregulation controls AR target gene expression, thereby promoting cancer progression.

Main Methods:

  • Literature review and synthesis of existing research on androgen receptor signaling in prostate cancer.
  • Analysis of molecular events affecting AR, including expression, mutation, and modification.
  • Examination of the roles of AR coactivators and corepressors in prostate cancer pathogenesis.

Main Results:

  • Deregulated expression and function of the AR are key factors in prostate cancer progression.
  • Alterations in AR coactivators and corepressors significantly impact cancer development.
  • Dysregulated AR signaling controls the selection and expression of AR target genes, driving tumor growth and metastasis.

Conclusions:

  • Understanding AR pathway deregulation is critical for deciphering prostate cancer progression.
  • Targeting AR and its associated regulatory proteins offers potential therapeutic strategies for prostate cancer.
  • Further research into AR target gene regulation is needed to fully elucidate its role in prostate cancer metastasis.

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