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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

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Published on: July 24, 2020

Imaging the cavernous nerves in the rat prostate using optical coherence tomography.

Nathaniel M Fried1, Soroush Rais-Bahrami, Gwen A Lagoda

  • 1Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. nmfried@uncc.edu

Lasers in Surgery and Medicine
|December 14, 2006
PubMed
Summary

Optical coherence tomography (OCT) successfully imaged rat cavernous nerves (CNs), aiding in visualization during prostatectomy. This technique shows promise for improving nerve preservation and post-operative erectile function.

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Area of Science:

  • Urology
  • Surgical Technology
  • Medical Imaging

Background:

  • Cavernous nerves (CNs) are crucial for erectile function and can be damaged during radical prostatectomy.
  • Improved visualization of CNs may enhance nerve preservation and post-operative potency.
  • Optical coherence tomography (OCT) offers real-time, high-resolution, in vivo tissue imaging.

Purpose of the Study:

  • To evaluate the utility of OCT for imaging rat cavernous nerves (CNs).
  • To correlate OCT images with histological analysis and functional measurements.
  • To provide an interpretation of prostate structures visualized with OCT.

Main Methods:

  • OCT imaging was performed using the Niris system with a handheld probe on six male rats.
  • Images of the prostate, CNs, pelvic plexus ganglion, seminal vesicle, blood vessels, and fat were acquired.
  • CN electrical stimulation and histological analysis confirmed OCT findings.

Main Results:

  • Cross-sectional and longitudinal OCT images of CNs were acquired and compared to histology.
  • OCT successfully differentiated CNs and ganglia from surrounding prostate tissues and vasculature.
  • Histological correlation confirmed the accuracy of OCT-based identification.

Conclusions:

  • Preliminary OCT imaging of rat CNs shows high resolution and accuracy.
  • OCT provides valuable real-time visualization of CNs and associated structures.
  • This technique holds potential for improving surgical outcomes in prostatectomy.