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Updated: Jul 18, 2026
06:48
A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
Published on: June 16, 2022
Micromanagement: a role for microRNAs in mRNA stability
1Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208103, New Haven, Connecticut 06520-8103, USA.
ACS Chemical Biology
|December 14, 2006
Abstract:
Small, inhibitory RNA molecules called microRNAs cause large decreases in target protein levels through a post-transcriptional mechanism. Until recently, it was believed this mechanism operated almost exclusively at a step in translation. However, new work has revealed that microRNAs have a second, post-transcriptional mechanism that accelerates the rate of deadenylation, the initial step of mRNA decay.
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