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Identification of a Smad phosphatase

Caroline S Hill1

  • 1Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, United Kingdom. caroline.hill@cancer.org.uk

ACS Chemical Biology
|December 14, 2006
PubMed
Summary

Researchers discovered that PPM1A functions as a Smad phosphatase, effectively terminating transforming growth factor-beta (TGF-β) signaling pathways. This finding clarifies a key mechanism for regulating cellular responses to TGF-β.

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