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Related Experiment Videos

What is a mood stabilizer?

Guy M Goodwin1, Gin S Malhi

  • 1University Department of Psychiatry, Warnford Hospital, Oxford, UK.

Psychological Medicine
|December 14, 2006
PubMed
Summary
This summary is machine-generated.

Mood stabilizers are widely used but lack regulatory approval. A critical review of drug efficacy is needed to ensure this important label is applied judiciously to agents that truly deliver.

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Area of Science:

  • Psychiatry and Pharmacology
  • Neuroscience
  • Clinical Therapeutics

Background:

  • The term 'mood stabilizer' is widely used in clinical practice for bipolar disorder treatment.
  • Despite widespread use, mood stabilizers lack official recognition from regulatory authorities worldwide.
  • The ideal mood stabilizer should treat acute episodes and prevent recurrences, a standard few drugs meet.

Discussion:

  • This review critically examines the definition and eligibility criteria for mood stabilizers.
  • It assesses which agents, if any, meet the gold standard for mood stabilization.
  • The importance of judicious application of the 'mood stabilizer' label is emphasized.

Key Insights:

  • Lithium is a notable exception, closely approximating the gold standard for mood stabilization.

Related Experiment Videos

  • Many agents are prematurely labeled as mood stabilizers without meeting rigorous efficacy criteria.
  • Revisiting the definition ensures the label is reserved for drugs that demonstrably deliver therapeutic benefits.

    • Outlook:

    • Accurate classification of mood stabilizers is crucial for treatment guidelines and novel drug development.
    • The term 'mood stabilizer' must be reserved for agents that provide tangible clinical benefits.
    • Future research should focus on developing and validating agents that truly fulfill the promise of mood stabilization.