Current advances in the diagnosis of vasospasm

Symptomatic vasospasm leading to delayed ischemia and neurological deficits is one of the most serious complications after aneurysmal subarachnoid hemorrhage (SAH). Reliable and early detection of symptomatic vasospasm is one of the major goals in the management of patients with SAH. In awake patients, the close clinical neurological examination still remains the most important diagnostic measure. In comatous or sedated patients, cerebral angiography remains the mainstay of the diagnostic workup for vasospasm. However, angiography does not allow assessing the hemodynamic relevance of vasospasm and is not suited for early identification of cerebral hypoperfusion and ischemia. Therefore, a large panel of new monitoring techniques for the assessment of regional cerebral perfusion has been recently introduced into the clinical management of SAH patients. This article briefly reviews the most relevant methods for monitoring cerebral perfusion and discusses their clinical predictive value for the diagnosis of vasospasm. On the basis of the currently available monitoring technologies, an algorithm for the diagnosis of vasospasm is presented.