Contribution of the remodeling response to cerebral vasospasm

The authors review the remodeling response of blood vessels that occurs after various injuries to arteries. The role of this response in vasospasm after subarachnoid hemorrhage (SAH) is reviewed. There is some evidence that cerebral arteries remodel after SAH in that they are less compliant and contractile than normal. Evidence for other features, such as alteration of smooth muscle phenotype, proliferation of cells and synthesis of extracellular matrix, is conflicting and requires a further study. A remodeling response probably contributes to vasospasm but the magnitude of its importance, in relation to smooth muscle contraction, which also occurs, also needs to be further defined.