Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Venous Thrombosis IV: Nursing Management

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

Coronary Artery Disease V: Interprofessional Care

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discontinuation of warfarin prior to elective invasive procedures.

Danish medical journal·2025

Same author

Control of warfarin treatment in patients with antiphospholipid syndrome and falsely high INR at point-of-care-testing.

Thrombosis research·2025

Same author

Principles of reversal of anticoagulation in patients with intracerebral hemorrhage related to oral anticoagulants.

European stroke journal·2025

Same author

Interfering antibodies may contribute to elevated D-dimer: a case report.

Journal of medical case reports·2024

Same author

Graduated elastic compression stockings in the prevention of post-thrombotic syndrome: A systematic review and meta-analysis.

Phlebology·2023

Same author

Application of Activators Ecarin and Factor Xa in Thrombelastography for Measurement of Anticoagulant Effect of Direct Oral Anticoagulants Using TEG 5000.

Seminars in thrombosis and hemostasis·2022

Search research articles

Related Experiment Videos

[The antithrombotic-treated patient].

Jørn Dalsgaard Nielsen¹, Hans Morten Schnack Rasmussen, Steen Elkjaer Husted

¹Amtssygehuset i Gentofte, Trombosecentret, Klinisk-biokemisk Afdeling, H:S Bispebjerg Hospital, Hellerup. jdn@dadlnet.dk

Ugeskrift for Laeger

|December 14, 2006

Summary

Managing patients on antithrombotic therapy requires careful risk assessment for bleeding and thromboembolism. Understanding drug effects and reversal agents is crucial for safe perioperative outcomes in both elective and emergency procedures.

Related Experiment Videos

Area of Science:

Cardiology
Pharmacology
Anesthesiology

Context:

Perioperative management of patients on antithrombotic agents presents significant clinical challenges.
Balancing the risks of bleeding and thromboembolism is critical for patient safety during invasive procedures.

Purpose:

To highlight the importance of preoperative risk assessment for bleeding and thromboembolism.
To emphasize the need for knowledge of antithrombotic drug pharmacokinetics, pharmacodynamics, and reversal strategies.

Summary:

Preoperative evaluation of bleeding and thromboembolic risk is essential for patients undergoing invasive procedures while on antithrombotic therapy.
In emergency situations, understanding antithrombotic drug properties and the role of hemostatic agents is vital.

Impact:

Facilitates safer management of patients on anticoagulants and antiplatelet drugs.
Improves clinical decision-making in perioperative antithrombotic therapy.
Reduces complications associated with antithrombotic drug use during surgery.