Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Studies on diterpenoids from Andrographis paniculata].

Li-Xia Chen1, Ge-Xia Qu, Feng Qiu

  • 1Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|December 15, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physalins V-IX, 16,24-cyclo-13,14-seco withanolides from Physalis angulata and their antiproliferative and anti-inflammatory activities.

Scientific reports·2017
Same author

Nine pairs of megastigmane enantiomers from the leaves of Eucommia ulmoides Oliver.

Journal of natural medicines·2017
Same author

Impact of the Publication of Appropriate Use Criteria on Utilization Rates of Myocardial Perfusion Imaging Studies in Ontario, Canada: A Population-Based Study.

Journal of the American Heart Association·2017
Same author

Stress testing after percutaneous coronary interventions: a population-based study.

CMAJ open·2017
Same author

Metabolic profiling of quercetin in rats using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

Biomedical chromatography : BMC·2017
Same author

[Resiquimod (R848) has more stronger immune adjuvantivity than other tested TLR agonists].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·2017
Same journal

[TCM understanding and classical formula treatment strategies for type 2 diabetes mellitus].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same journal

[Assessment of therapeutic effectiveness and underlying pharmacological mechanisms of Tripterygium glycosides for systemic lupus erythematosus: umbrella review and in silico study].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same journal

[Psoralen attenuates skeletal muscle atrophy in mice with heart failure after myocardial infarction by regulating NLRP3/Caspase-1/GSDMD pathway].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same journal

[Shared mechanisms of obesity and male infertility and prediction of natural therapeutics based on machine learning and single-cell sequencing].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same journal

[Mechanism study on treating psoriasis of blood-heat type with Tuhuaidan Siwu Decoction based on metabolomics and p38 MAPK/NF-κB signaling pathway].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same journal

[Regulatory effects of serum containing Hedysari Radix Praeparata Cum Melle-vinegar processed Curcumae Rhizoma on mitochondrial function and mitophagy in HT-29 cells].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
See all related articles

This study isolated fourteen diterpenoids from Andrographis paniculata, including a new natural product (compound 7) and a previously unreported compound from this species (compound 5). These findings expand the known chemical constituents of Andrographis paniculata.

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacognosy

Background:

  • Andrographis paniculata is a medicinal herb with a rich history of use in traditional medicine.
  • The plant is known to contain various bioactive compounds, primarily diterpenoids.
  • Understanding its chemical constituents is crucial for exploring its therapeutic potential.

Purpose of the Study:

  • To isolate and identify diterpenoids from the 85% ethanol extract of Andrographis paniculata aerial parts.
  • To characterize novel or previously unreported compounds from this species.

Main Methods:

  • Extraction of aerial parts of Andrographis paniculata using 85% ethanol.
  • Isolation of diterpenoids using silica gel, Sephadex LH-20, and ODS column chromatography, followed by HPLC.

Related Experiment Videos

  • Structure elucidation through spectral analyses and chemical evidence.

    • Main Results:

    • Fourteen diterpenoids were successfully isolated and identified.
    • The identified compounds include neoandrographolide, andrographolide, andrographiside, and several deoxy derivatives.
    • Compound 7 (3-oxo-14-deoxy-andrographolide) was identified as a new natural product.
    • Compound 5 (19-hydroxy-8(17),13-labdadien-15,16-olide) was isolated for the first time from Andrographis species.

    Conclusions:

    • The study successfully identified fourteen diterpenoids from Andrographis paniculata.
    • A new natural product, compound 7, was discovered.
    • Compound 5 represents a novel finding for this plant species, contributing to the known phytochemical profile of Andrographis paniculata.